221 research outputs found

    Altered Serum IgG Levels to a-Synuclein in Dementia with Lewy Bodies and Alzheimer’s Disease.

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    Natural self-reactive antibodies in the peripheral blood may play a considerable role in the control of potentially toxic proteins that may otherwise accumulate in the aging brain. The significance of serum antibodies reactive against asynuclein is not well known. We explored serum IgG levels to monomeric a-synuclein in dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) with a novel and validated highly sensitive ELISA assay. Antibody levels revealed stark differences in patients compared to healthy subjects and were dependent on diagnosis, disease duration and age. Anti-asynuclein IgG levels were increased in both patient groups, but in early DLB to a much greater extent than in AD. Increased antibody levels were most evident in younger patients, while with advanced age relatively low levels were observed, similar to healthy individuals, exhibiting stable antibody levels independent of age. Our data show the presence of differentially altered IgG levels against a-synuclein in DLB and AD, which may relate to a disturbed a-synuclein homeostasis triggered by the disease process. These observations may foster the development of novel, possibly preclinical biomarkers and immunotherapeutic strategies that target a-synuclein in neurodegenerative disease.Fil: Koehler, Niklas. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Stransky, Elke. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Shing, Mona. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Gaertner, Susanne. Department of Psychiatry and Psychotherapy, EBERHARD-KARLS-UNIVERSITY;Fil: Meyer, Mirjam. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Schreitmueller, Brigitte. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Leyhe, Thomas. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Laske, Cristoph. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Maetzler, Walter. Department of Neurodegeneration. HERTIE INSTITUTE FOR CLINICAL BRAIN RESEARCH;Fil: Kahle, Philipp. FUNCTIONAL NEUROGENETICS. HERTIE INSTITUTE FOR CLINICAL;Fil: Celej, Maria Soleda. MAX-PLANCK-INSTITUTE FOR BIOPHYSICAL CHEMISTRY; Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Centro de Invest.en Qca.biol.de Cordoba (p);Fil: Jovin, Thomas M.. MAX-PLANCK-INSTITUTE FOR BIOPHYSICAL CHEMISTRY;Fil: Fallgatter, Andreas. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Batra, Anil. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Buchkremer, Gherard. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Schott, Klauss. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY;Fil: Richartz-Salzburger, Elke. Department of Psychiatry and Psychotherapy. EBERHARD-KARLS-UNIVERSITY

    Observation of a charged charmoniumlike structure in e+e(DDˉ)±πe^+e^- \to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp at s=4.26\sqrt{s}=4.26GeV

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    We study the process e+e(DDˉ)±πe^+e^- \to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp at a center-of-mass energy of 4.26GeV using a 827pb1^{-1} data sample obtained with the BESIII detector at the Beijing Electron Positron Collider. Based on a partial reconstruction technique, the Born cross section is measured to be (137±9±15)(137\pm9\pm15)pb. We observe a structure near the (DDˉ)±(D^{*} \bar{D}^{*})^{\pm} threshold in the π\pi^\mp recoil mass spectrum, which we denote as the Zc±(4025)Z^{\pm}_c(4025). The measured mass and width of the structure are (4026.3±2.6±3.7)(4026.3\pm2.6\pm3.7)MeV/c2^2 and (24.8±5.6±7.7)(24.8\pm5.6\pm7.7)MeV, respectively. Its production ratio σ(e+eZc±(4025)π(DDˉ)±π)σ(e+e(DDˉ)±π)\frac{\sigma(e^+e^-\to Z^{\pm}_c(4025)\pi^\mp \to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp)}{\sigma(e^+e^-\to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp)} is determined to be 0.65±0.09±0.060.65\pm0.09\pm0.06. The first uncertainties are statistical and the second are systematic.Comment: 7 pages, 4 figures, 1 table; version accepted to be published in PR

    Search for the radiative transitions ψ(3770)γηc\psi(3770)\to\gamma\eta_c and γηc(2S)\gamma\eta_c(2S)

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    By using a 2.92 fb1^{-1} data sample taken at s=3.773\sqrt{s} = 3.773 GeV with the BESIII detector operating at the BEPCII collider, we search for the radiative transitions ψ(3770)γηc\psi(3770)\to\gamma\eta_c and γηc(2S)\gamma\eta_c(2S) through the hadronic decays ηc(ηc(2S))KS0K±π\eta_c(\eta_c(2S))\to K^0_SK^\pm\pi^\mp. No significant excess of signal events above background is observed. We set upper limits at a 90% confidence level for the product branching fractions to be B(ψ(3770)γηc)×B(ηcKS0K±π)<1.6×105\mathcal{B}(\psi(3770)\to\gamma\eta_c)\times \mathcal{B}(\eta_c\to K^0_SK^\pm\pi^\mp) < 1.6\times10^{-5} and B(ψ(3770)γηc(2S))×B(ηc(2S)KS0K±π)<5.6×106\mathcal{B}(\psi(3770)\to\gamma\eta_c(2S))\times \mathcal{B}(\eta_c(2S)\to K^0_SK^\pm\pi^\mp) < 5.6\times10^{-6}. Combining our result with world-average values of B(ηc(ηc(2S))KS0K±π)\mathcal{B}(\eta_c(\eta_c(2S))\to K^0_SK^\pm\pi^\mp), we find the branching fractions B(ψ(3770)γηc)<6.8×104\mathcal{B}(\psi(3770)\to\gamma\eta_c) < 6.8\times10^{-4} and B(ψ(3770)γηc(2S))<2.0×103\mathcal{B}(\psi(3770)\to\gamma\eta_c(2S)) < 2.0\times10^{-3} at a 90% confidence level.Comment: 10 pages, 4 figure

    Search for Baryonic Decays of \psi(3770) and \psi(4040)

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    By analyzing data samples of 2.9 fb^{-1} collected at \sqrt s=3.773 GeV, 482 pb^{-1} collected at \sqrt s=4.009 GeV and 67 pb^{-1} collected at \sqrt s=3.542, 3.554, 3.561, 3.600 and 3.650 GeV with the BESIII detector at the BEPCII storage ring, we search for \psi(3770) and \psi(4040) decay to baryonic final states, including \Lambda\bar\Lambda\pi^+\pi^-, \Lambda \bar\Lambda\pi^0, \Lambda\bar\Lambda\eta, \Sigma^+ \bar\Sigma^-, \Sigma^0 \bar\Sigma^0, \Xi^-\bar\Xi^+ and \Xi^0\bar\Xi^0 decays. None are observed, and upper limits are set at the 90% confidence level.Comment: 9 pages, 3 figure

    Search for the Lepton Flavor Violation Process J/ψeμJ/\psi \to e\mu at BESIII

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    We search for the lepton-flavor-violating decay of the J/ψJ/\psi into an electron and a muon using (225.3±2.8)×106(225.3\pm2.8)\times 10^{6} J/ψJ/\psi events collected with the BESIII detector at the BEPCII collider. Four candidate events are found in the signal region, consistent with background expectations. An upper limit on the branching fraction of B(J/ψeμ)<1.5×107\mathcal{B}(J/\psi \to e\mu)< 1.5 \times 10^{-7} (90% C.L.) is obtained

    Precision Measurement of the Mass of the τ\tau Lepton

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    An energy scan near the τ\tau pair production threshold has been performed using the BESIII detector. About 2424 pb1^{-1} of data, distributed over four scan points, was collected. This analysis is based on τ\tau pair decays to eeee, eμe\mu, eheh, μμ\mu\mu, μh\mu h, hhhh, eρe\rho, μρ\mu\rho and πρ\pi\rho final states, where hh denotes a charged π\pi or KK. The mass of the τ\tau lepton is measured from a maximum likelihood fit to the τ\tau pair production cross section data to be mτ=(1776.91±0.120.13+0.10m_{\tau} = (1776.91\pm0.12 ^{+0.10}_{-0.13}) MeV/c2c^2, which is currently the most precise value in a single measurement.Comment: 13 pages, 7 figure

    Search for C-parity violation in J/ψγγJ/ \psi \to \gamma\gamma and γϕ \gamma \phi

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    Using 1.06×1081.06\times10^8 ψ(3686)\psi(3686) events recorded in e+ee^{+}e^{-} collisions at s=\sqrt{s}= 3.686 GeV with the BESIII at the BEPCII collider, we present searches for C-parity violation in J/ψγγJ/\psi \to \gamma\gamma and γϕ \gamma \phi decays via ψ(3686)J/ψπ+π\psi(3686) \to J/\psi \pi^+\pi^-. No significant signals are observed in either channel. Upper limits on the branching fractions are set to be B(J/ψγγ)<2.7×107\mathcal{B}(J/\psi \to \gamma\gamma) < 2.7 \times 10^{-7} and B(J/ψγϕ)<1.4×106\mathcal{B}(J/\psi \to \gamma\phi) < 1.4 \times 10^{-6} at the 90\% confidence level. The former is one order of magnitude more stringent than the previous upper limit, and the latter represents the first limit on this decay channel.Comment: 7 pages, 2 figure

    Observation of J/ψppˉa0(980)J/\psi \rightarrow p\bar{p}a_{0}(980) at BESIII

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    Using 2.25×1082.25\times10^{8} J/ψJ/\psi events collected with the BESIII detector at the BEPCII storage rings, we observe for the first time the process J/ψppˉa0(980)J/\psi\rightarrow p\bar{p}a_{0}(980), a0(980)π0ηa_{0}(980)\rightarrow \pi^{0}\eta with a significance of 6.5σ6.5\sigma (3.2σ3.2\sigma including systematic uncertainties). The product branching fraction of J/ψppˉa0(980)ppˉπ0ηJ/\psi\rightarrow p\bar{p}a_{0}(980)\rightarrow p\bar{p}\pi^{0}\eta is measured to be (6.8±1.2±1.3)×105(6.8\pm1.2\pm1.3)\times 10^{-5}, where the first error is statistical and the second is systematic. This measurement provides information on the a0a_{0} production near threshold coupling to ppˉp\bar{p} and improves the understanding of the dynamics of J/ψJ/\psi decays to four body processes.Comment: 8 pages, 7 figure

    Observation of e+eπ0π0hce^+e^-\to \pi^0\pi^0 h_c and a neutral charmoniumlike structure Zc(4020)0Z_c(4020)^0

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    Using data collected with the BESIII detector operating at the Beijing Electron Positron Collider at center-of-mass energies of s=4.23\sqrt{s}=4.23, 4.26, and 4.36~GeV, we observe \EE\to \pphc for the first time. The Born cross sections are measured and found to be about half of those of \EE\to \pi^+\pi^-h_c within less than 2σ\sigma. In the π0hc\pi^0h_c mass spectrum, a structure at 4.02~GeV/c2c^2 is found. It is most likely to be the neutral isospin partner of the \zcp^{\pm} observed in the process of \EE\to \pi^+\pi^-h_c is found. A fit to the π0hc\pi^0 h_c invariant mass spectrum, with the width of the \zcpn fixed to that of its charged isospin partner and possible interferences with non-\zcpn amplitudes neglected, gives a mass of (4023.9±2.2±3.84023.9\pm 2.2 \pm 3.8)~MeV/c2c^2 for the \zcpn, where the first error is statistical and the second systematic.Comment: 7 pages, 2 figure
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